The Picornaviruses by Ellie Ehrenfeld, Esteban Domingo, Raymond P. Roos

By Ellie Ehrenfeld, Esteban Domingo, Raymond P. Roos

A springboard for constructing new ways to knowing, combating, and treating picornaviral illnesses.

  • Examines the most up-tp-date breakthroughs in addition to the demanding situations that lie forward in picornavirus examine; encapsulates present wisdom of the molecular biology, evolution, and pathogenesis of this massive relatives of viruses; and, examines the illnesses that those viruses reason and the newest vaccines and antiviral medicines to avoid and keep watch over these illnesses.
  • Explores the structural and mechanistic bases of picornavirus replication, highlighting new insights in regards to the host mobile interactions wanted for virus development; and, illustrates how the normal prevalence of mutations, standard of viruses with RNA as genetic fabric, generates the quasispecies dynamics that underlie viral health.
  • Focuses on picornaviruses that reason illness, interpreting pathogenicity and innate and bought immune responses opposed to an infection in addition to the most recent vaccine and antiviral drug concepts.

Show description

Read or Download The Picornaviruses PDF

Similar microbiology books

Lipidomics and Bioactive Lipids: Specialized Analytical Methods and Lipids in Disease

This quantity within the well-established tools in Enzymology sequence positive factors tools for the examine of lipids utilizing mass spectrometry ideas. Articles during this quantity hide themes comparable to Liquid chromatography mass spectrometry for quantifying plasma lysophospholipids: capability biomarkers for melanoma analysis; size of eicosanoids in melanoma tissues; Noninvasive evaluation of the position of Cyclooxygenases in Cardiovascular HealthA specific HPLC/MS/MS approach; Lipidomics in Diabetes and the Metabolic Syndrome; LC-MS-MS research of impartial Eicosanoids; Quantification Of F2-Isoprostanes In organic Fluids And Tissues As A degree Of Oxidant pressure; dimension of goods of Docosahexaenoic Acid Peroxidation, Neuroprostanes, and Neurofurans; Enantiomeric separation of hydroxy and hydroperoxy eicosanoids by way of chiral column chromatography; particular Chiral Lipidomics research by means of Liquid Chromatography Electron catch Atmospheric strain Chemical Ionization Mass Spectrometry (LC-ECAPCI/MS); Shotgun Lipidomics by means of Tandem Mass Spectrometry lower than Data-Dependent Acquisition keep an eye on; identity of Intact Lipid Peroxides through Ag+ Coordination Ionspray Mass Spectrometry (CIS-MS); Quantification of Cardiolipin via Liquid Chromatography Electrospray Ionization Mass Spectrometry.

Methods to Study Litter Decomposition: A Practical Guide

The first target of this e-book is to supply scholars and laboratory teachers at universities ecologists with a huge diversity of demonstrated how you can research plant muddle decomposition. specific protocols for direct use within the box or laboratory are awarded in a simple to stick to step by step structure.

Bio-Nanoparticles: Biosynthesis and Sustainable Biotechnological Implications

Nanoparticles are the development blocks for nanotechnology; they're higher equipped, durable, purifier, more secure, and smarter items to be used throughout industries, together with communications, drugs, transportation, agriculture and different industries. managed dimension, form, composition, crystallinity, and structure-dependent houses govern the original homes of nanotechnology.

Additional resources for The Picornaviruses

Example text

1999. Sequence analysis of a porcine enterovirus serotype 1 isolate: relationships with other picornaviruses. J. Gen. Virol. 80: 1929–1941. Donnelly, M. , G. Luke, A. Mehrotra, X. Li, L. E. Hughes, D. Gani, and M. D. Ryan. 2001. ’ J. Gen. Virol. 82:1013–1025. Duke, G. , J. E. Osorio, and A. C. Palmenberg. 1990. Attenuation of mengo virus through genetic engineering of the 5′ noncoding poly(C) tract. Nature 343:474–476. , and A. C. Palmenberg. 2001. Phenotypic characterization of three phylogenetically conserved stem-loop motifs in the mengovirus 3′ untranslated region.

Proc. Natl. Acad. Sci. USA 105:14124–14129. , and M. Costa-Mattioli. 2007. Genetic variability and molecular evolution of hepatitis A virus. Virus Res. 127: 151–157. Demakov, G. , S. N. Ostashev, V. N. Ogordnikova, and M. A. Shilov. 1975. Infection of brown rats with the duck hepatitis virus. Veterinariia 3:57–58. , D. Todd, N. McFerran, and E. M. Hoey. 1999. Sequence analysis of a porcine enterovirus serotype 1 isolate: relationships with other picornaviruses. J. Gen. Virol. 80: 1929–1941. Drake, M.

And S. de Breyne. 2007. A distinct group of hepacivirus/pestivirus-like internal ribosomal entry sites in members of diverse picornavirus genera: evidence for modular exchange of functional noncoding RNA elements by recombination. J. Virol. 81:5850–5863. Hellen, C. U. , and E. Wimmer. 1995. Enterovirus structure and assembly, p. 155–170. In H. A. ), Human Enterovirus Infections. ASM Press, Washington, DC. , Q. H. Li, R. Basavappa, J. M. Hogle, and M. Chow. 1999. Poliovirus mutants at histidine 195 of VP2 do not cleave VP0 into VP2 and VP4.

Download PDF sample

Rated 4.71 of 5 – based on 3 votes