Protagonists of Medicine by Domenico Ribatti (auth.)

By Domenico Ribatti (auth.)

The examine of scientific historical past is fascinating in itself and will support to switch the view occasionally expressed that scientific scholars and medical professionals are missing in tradition of any variety. furthermore, a few old point of view is usually positive while one is thinking about the multitude of advances which are now happening within the conception and perform of drugs.

This booklet, containing a chain of gathered papers relating immunology and pathology and vascular biology and angiogenesis, drives us via medical milestones within the heritage of medication during the prior centuries and highlights the contribution of pioneering scientists whose discoveries have lead the way to many researchers operating within the fields of cellphone biology, developmental biology, immunology, pathology, and oncology.

This publication will function a source for scientists, historians of medication and philosophers of technological know-how and medicine.

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G. chicken pox and vaccinia virus. They also resisted bacillus Calmette–Guérin infection quite normally (Good and Varco, 1955; Good, 1955, 1954; Good and Zak1956). , 1964). In several of these patients, the thymus was not only very small and very deficient in lymphoid development but also showed a failure of migration. The Di George third and fourth pharyngeal pouch syndrome patients had absence or deficiency of all cell-mediated immunological functions. They were also somewhat deficient in antibody production, but not so deficient as the patients with Bruton’s X-linked agammaglobulinaemia.

In 1967, Jerne explained that there were two kinds of immunologists, who hardly spoke to each other: the “trans-immunologists”, who were interested in the structure of the antibody molecule and its binding to the antigen, and the “cisimmunologists”, who were interested in the events following antigen exposure. The consequence of acceptance of the clonal theory of antibody synthesis on the other hand, and the progress in understanding the mechanism of protein synthesis and the role of cellular receptors in the regulation of immune phenomena on the other hand, reduced the distance between the cis- and trans-immunologists.

The thymus controls development of all cell-mediated immunities, including delayed reactions, allograft immunities and other immunologic functions. In addition to being a basic immunologist, Good also held the position of professor of pediatrics at the School of Medicine in Minneapolis, Minnesota. He thus had access to the various cases of immunodeficiencies that had led him to recognize similarities between Bruton’s agammaglobulinaemia and Glick’s BSX, on the one hand, and Di George syndrome and Miller’s thymectomized mice on the other hand.

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