By Ken Donaldson, Paul Borm
Particle Toxicology integrates the present wisdom in particulate physico-chemistry, cell/molecular biology and toxicology right into a unmarried quantity. whereas utilizing the classical toxicology paradigm of publicity — dose — reaction, it offers reports at the mechanisms and homes of pathogenic debris and their pathogenic results. The textual content describes how those activities can be with regards to particular web site of deposition, translocation, particle composition, form and the end result of assorted pathogenic strategies related to pro-inflammatory results and inflammatory signaling, oxidative and nitrosative pressure, particulate interactions within the pulmonary, cardiovascular, and valuable frightened structures, in addition to genotoxic results of ultrafine and different debris.
Read Online or Download Particle Toxicology PDF
Similar toxicology books
Viscum Album has been used as a therapy for a minimum of 2,000 years, these days predominantly in complementary melanoma remedy. regardless of an visible discrepancy among the recognition of mistletoe extracts and their category as a non-conventional remedy modality with unproven efficacy in oncology, mistletoe is among the most generally used adjuvant remedies of neoplastic issues, particularly in German talking components.
The recent variation of this profitable reference bargains either state of the art and vintage pharmacological equipment. completely revised and improved to 2 volumes, it bargains an up-to-date choice of the main usually used assays for reliably detecting the pharmacological results of power medicinal drugs. each bankruptcy has been up to date, and diverse assays were further.
This ebook presents for the 1st time a unmarried finished resource of data at the analytical chemistry of nicotine and comparable alkaloids. The editors have introduced jointly scientists from academia and the tobacco to explain the cutting-edge of the chemistry and analytical tools for dimension of nicotine.
Pt. 1. floor amendment ideas -- pt. 2. Analytical options and purposes
- Principles and Methods of Toxicology
- Drug - Drug Interactions (Drugs and the Pharmaceutical Sciences)
- Handbook of Nanotoxicology, Nanomedicine and Stem Cell Use in Toxicology
- In Vitro Toxicology Systems
- Principles and Methods of Toxicology, Fifth Edition
Extra resources for Particle Toxicology
Vermiculite deposits contain a range of other minerals that were formed at the same time. Of particular concern are vermiculite deposits from some sources that have been found to contain amphibole asbestiform minerals (Van Gosen et al. 0921—CHAPTER 2—16/11/2006—14:49—SJAPPIYAR—15549—XML MODEL C – pp. 13–45 Mineralogy and Structure of Pathogenic Particles 19 2002; Gunter 2004; McDonald, Harris, and Armstrong 2004; Pfau et al. 2005), such as tremolite and actinolite. When subjected to high temperatures, vermiculite has the unusual property of exfoliating or “popping” into worm-like pieces (Latin vermiculare: to breed worms).
2004; Forbes et al. 2004). Minerals are the building blocks of rocks, therefore, on occasion we have to consider assemblages of minerals forming a rock type, which itself has been implicated in adverse respiratory health effects. An example of this would be “bauxite,” the common name for aluminum ore derived from weathered igneous rocks. Bauxite consists of a mixture of aluminum hydroxide minerals, the most abundant of which is gibbsite, plus other major, minor, and trace minerals. There is an occupational respiratory disease unique to bauxite miners, “Shaver’s Disease,” but this has only been linked to the ore “bauxite,” and not to any individual component mineral (Dinman 1988; Radon et al.
3 CHAIN SILICATES The chain silicates are notable as they contain the carcinogenic minerals crocidolite and amosite. Chain silicates are a group of minerals with their tetrahedrons in single or multiple chains, with two oxygen atoms of each tetrahedron forming part of the adjoining tetrahedron. Amphiboles are a group of inosilicate minerals, containing hydroxyl (OH) groups, with double chains of aligned silicate tetrahedra. They exist in two different systems, orthorhombic (orthoamphibole) and monoclinic (clinoamphibole).