By F. Lehmann-Grube (auth.)
I. advent Of the ever expanding variety of viruses identified to impact guy and better animals, the virus of lymphocytic choriomeningitis (LCM) used to be one of many first to be came upon. certainly, this virus has been recognized and maintained within the laboratory via passages in a comparatively uncomplicated host, the mouse, for 35 years. but our knowl fringe of its houses continues to be scanty compared to the wealth of informa tion to be had for different viruses, a few of that have come to our cognizance even more lately. There are a minimum of 4 purposes which can aid to provide an explanation for this seeming paradox. (1) The early trust that the LCM virus used to be the common reason for human ailments had quickly to be deserted; infections of guy with this virus are infrequent. (2) in terms of distinction, laboratory infections will not be unusual they usually usually run serious or even deadly classes. (3) till lately, the single technique of titrating the virus used to be by means of mouse inoculation, a style during which accuracy and economic climate are poorly correlated. (4) The virus is of bizarre lability, being fast inactivated less than stipulations which go away different viruses intact. hence, whilst balancing scientific and theoretical value opposed to own probability and tech nical problems, the end result was once really adverse, and shortage of curiosity used to be fairly no longer marvelous. within the previous couple of years, even if, the placement has progressively replaced and increasingly more staff have became their realization to this virus.
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Extra resources for Lymphocytic Choriomeningitis Virus
At limiting dilutions some mice did not react locally even though they had been infected as evinced by later immunity to intracerebral challenge. Thus the titer based on infection may be higher than the one based on the local response, which is reminiscent of the difference between IDso and LDso after intracerebral inoculation (see Section XI. A. 1) and may best be e:x;plained along 30 F. Lehmann·Grube: Lymphocytic Choriomeningitis Virus similar lines, i. e. spilling of virus into the blood stream.
Ges. Virusforsch. 24, 220 (1968) (With Permission of the Author) Time after inoculation 1 day 2 days 3 days 5 days 12 hours I Site of inoculation eNS Liver Spleen Kidneys Blood Lymph nodes Thymus Other 0 0 0 0 0 0 0 0 0 + + + 0 0 0 0 0 0 I ++ ++ ++ ++ + + 0 0 0 I ++++ +++ +++ +++ ++ ++ ++ ++ ++ I ++++ ++++ ++++ ++++ ++++ +++ ++++ ++++ ++++ the fluorescent cells were found throughout the central nervous system and although it was usually not possible to distinguish between cell types the location indicated that neurones were heavily involved.
A. Mouse (Mus Musculus) 1. Signs of the Disease in Adult Mice The intracerebral infection of the adult mouse with the LCM virus is followed by a characteristic illness. This has been described by many writers, and rather than add a new version I shall quote RIVERS and SCOTT (1936a) whose description is pre-eminent in conciseness and clarity. "During the first 5 days after inoculation the mice appear well. Occasionally on the 5th, but more commonly on the 6th day, symptoms appear, at which time some of the mice may be found dead although none of them were obviously sick on the preceding day, while others with dirty, ruffled fur, half-closed eyes, and hunched backs remain motionless.