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5060－5069 Takigawa Y. & Brown AM. (2008). Wnt signaling in liver cancer. Curr Drug Targets. 1013-24. et al. (2007). MRP1 & PI3K/Akt multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blasts. 427–438. , Martina JA. & Rosa Puertollano. (2011). LAPTMs regulate lysosomal function and interact with mucolipin 1: new clues for understanding mucolipidosis type IV. , Song YY. & Xu W.
2003). , 2009). One of the GPC3 tumorigenic roles is the activation of Wnt/β-catenin signaling. , 2005). The heparin sulfate chain of GPC3 is reported to bind with basic growth factors such as FGF-2. , 2003). This interaction plays a role in the increase of HCC cell proliferation, and growth of tumor in nude mouse model. , 2008). Though yet to be elucidated, the GPC3-hedgehog signaling is suggested to contribute to HCC development. Targeting GPC3 and its related growth signaling is a relevant approach to inhibit HCC growth.
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