DNA Methylation Epigenetics and Metastasis by M. Esteller

By M. Esteller

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MFF is funded by the Spanish Association against Cancer (AECC). REFERENCES 1. Fearon E. , Vogelstein B. A genetic model for colorectal tumorigenesis. Cell, 1990; 61:759-767. 2. , Balmain A. Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis. Nature, 1986; 322:78-80. 3. , Wood A. , Skalka A. M. Mutagenesis of the Ha-ras oncogene in mouse skin tumors induced by polycyclic aromatic hydrocarbons. Proc Natl Acad Sci U S A, 1986; 83:6048-6052. 4. Yuspa S. H. The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis--Thirty-Third G.

Searching for new methylated genes by combining cDNA microarray technology with 5-aza-2-deoxycytidine treatment. A. Measurement of 5-methylcytosine content by HPCE in mouse skin cancer cell lines treated and untreated with 5-aza-2-deoxycytidine. Results are expressed as the mean ± SD. B. representative blocks of a MouseChip array showing overexpression (red circles) of igfbp3 gene in CarC cell line relative to MCA3D. C. Summary of the methylation-specific PCR (MSP) and bisulfite sequencing analyses of the CpG island methylation status of five positive genes in the DNA microarray.

1). It is essential for tissue organization during development and for the maintenance of tissue integrity in adult organisms (18). Multicellular organisms have specialized cells, epithelial and endothelial that form selective barriers between tissues and different body compartments. , they have an apical domain and a basolateral domain and they adhere to each other through complexes that form junctions between the neighboring cells. 30 Figure 1. Types of cellular junctions and components of the extracellular matrix that play a role in invasion and metastasis.

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