By Marco Del Chiaro, Stephan L. Haas, Richard D. Schulick
This e-book offers a close, updated evaluation of cystic tumors of the pancreas, with assurance of all points of prognosis and therapy (medical, endoscopic, and surgical). After beginning chapters on pathology and type, cytology, molecular biology, and epidemiology, the function of every of the suitable diagnostic tools is punctiliously tested. The treatment-related chapters describe surgical methods, together with minimally invasive surgical procedure, in addition to ablation modalities and chemo-radiotherapy. Thorough assistance is usually supplied particularly at the administration of cystic tumors in high-risk instances and on follow-up. The authors are worldwide opinion leaders of their box who've contributed state of the art chapters, with emphasis on transparent diagnostic and healing algorithms and with quite a few helping tables and illustrations.
Owing to the frequent use of imaging modalities, clinicians are being faced via progressively more sufferers with cystic tumors of the pancreas, starting from benign cysts to metastasized malignancies. The widening spectrum of accessible diagnostic measures has ended in controversy over the alternative of extra technique of research while cystic alterations are encountered, and the expansion in healing suggestions has equally been observed by way of huge debate over their use. by contrast history, Cystic Tumors of the Pancreas should be a invaluable resource of appropriate info for either clinicians and surgeons and also will be of curiosity to radiologists, pathologists, and uncomplicated scientists.
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Additional info for Cystic Tumors of the Pancreas: Diagnosis and Treatment
Gastric-type epithelial cells can progress from low-grade to high-grade dysplasia, and these higher grade gastric-type cells can be impossible to distinguish from the other cell types. It is not necessary to make such a specific diagnosis of cell type on cytology. The most important distinction is between low-grade cells and high-grade cells since it is the high-grade cells that will represent a high-risk feature for malignancy. MCN are lined by mucinous epithelial cells similar to gastric-type epithelial cells.
1999;23(11):1320–7. 56. Reddy S, Cameron JL, Scudiere J, et al. Surgical management of solid-pseudopapillary neoplasms of the pancreas (Franz or Hamoudi tumors): a large singleinstitutional series. J Am Coll Surg. 2009;208(5):950– 7. discussion 957–9. 57. Raman SP, Kawamoto S, Law JK, et al. Institutional experience with solid pseudopapillary neoplasms: focus on computed tomography, magnetic resonance imaging, conventional ultrasound, endoscopic ultrasound, and predictors of aggressive histology.
5, documentation of cyst fluid CEA elevation, or molecular analysis documenting KRAS, GNAS, or RNF43 mutation (see above). Grading atypia requires cytological analysis of the cells. Detection of mutations known to occur late in progression to malignancy such as TP53 or deletion of SMAD4 supports malignancy [17, 18]. 4 Fig. 8 IPMN with high-grade dysplasia. Cells are small (<12 μm duodenal enterocyte), often in small clusters, and singly, with abnormal chromatin and typically associated with background necrosis (Papanicolaou) Secondarily cystic neoplasms include solid pseudopapillary neoplasm, neuroendocrine tumor, acinar cell carcinoma, and conventional ductal adenocarcinoma.