By M.D. Peter G. Bourne
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S. Z. eds. , 1970. pp 237-275. R. Cardiopulmonary resuscitation. X4iW/4, 193:678-679, 1965. ; and Genton, E. Methadoneinduced pulmonary edema. 218:882-883,1971. ; and Rose, J. The major medical complications of heroin ddáicXion. Ann Intern Med, 6 7 : 1 - 2 3 , 1967. V. Management of emergencies. XIV. Cardiac arrest. Ν Engl J Med, 275:35-39,1966. National Academy of Sciences, National Research Council. Cardiopulmonary resuscitation. X4M4, 198:372-379,1966. S. The clinical spectrum of heroin pulmonary Qá^m^.
A n y p a t i e n t w h o requires n a l o x o n e for t h e reversal of respiratory depression should be observed for 6 - 8 hr. T h e presence of p u l m o n a r y e d e m a is an i n d i c a t i o n for hospitalization for 2 4 - 4 8 hr. This will allow o p p o r t u n i t y for a general medical assessment of t h e p a t i e n t , search for o t h e r medical c o m p l i c a t i o n s of n a r c o t i s m , a n d observation for t h e late c o m p l i c a t i o n s m e n t i o n e d previously.
G. L A A M ) r e s p i r a t o r y depression could p o t e n t i a l l y occur b e y o n d 72 h r after admission. B. v. ) m a y be necessary every 2 - 3 h r t o treat respiratory depression. Again, t h e smallest dose which will reverse respiratory depression should be given, since t h e danger of precipitating w i t h d r a w a l c o n t i n u e s t o exist in t h e a d d i c t . S o m e physicians suggest an e x t e n d e d p r o p h y l a c t i c n a l o x o n e infusion, after an initial favorable response (Waldron, Klimt, a n d Seibel, 1 9 7 3 ) .